The lock and key hypothesis states that the substrate fits perfectly into the enzyme, like a lock and a key would. This is in contrast with the induced fit hypothesis, which states that both the substrate and the enzyme will deform a little to take on a shape that allows the enzyme to bind the substrate.Click to see full answer. Considering this, what is a lock and key model?The lock and key model also called Fisher’s theory is one of two models which describe the enzyme-substrate interaction. The lock and key model assumes that the active site of the enzyme and the substrate are equal shaped. It supposes that the substrate fits perfectly into the active site of the enzyme.One may also ask, who proposed lock and key hypothesis? …and enzyme, called the “key–lock” hypothesis, was proposed by German chemist Emil Fischer in 1899 and explains one of the most important features of enzymes, their specificity. In most of the enzymes studied thus far, a cleft, or indentation, into which the substrate fits is found at the active… Furthermore, what is the the lock and key mechanism? lock-and-key mechanism A mechanism proposed in 1890 by Emil Fischer (1852–1919) to explain binding between the active site of an enzyme and a substrate molecule. The active site was thought to have a fixed structure (the lock), which exactly matched the structure of a specific substrate (the key).What is the difference between induced fit and lock and key?Lock and Key states that there is no change needed and that only a certain type will fit. However induced fit says the active site will change to help to substrate fit. In lock and key the active site has one single entry however in induced fit the active site is made of two components.
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